The Comfort Zone disperses dog-appeasing pheromone, which mimics a natural comforting pheromone produced by dogs. It helps to calm dogs or puppies in stressful situations and reduces stress or boredom behaviors including barking, whimpering, whining, and chewing. Calms dogs during thunderstorms and fireworks or when left home alone. Also reduces or eliminates separation anxiety. D.A.P. mimics a natural reassuring pheromone produced by female dogs when nursing. Product is odorless and non-toxic, does not affect humans. Not a drug or tranquilizer. Ingredients: Canine "appeasing" pheromone 2%, excipients to 100 g. To use: simply plug the unit into an outlet in the room your pet frequents; effective in areas up to 600 square feet. Comes with one plug-in and one 48 ml bottle (1.691 oz.). Refills sold separately